Safety and application of the hottest plasticizer

2022-07-23
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Safety and application of plasticizer ATBC, With 10 ~ 30ml/KGg agent "We can't predict where the designed strength will take us, and the amount will have no effect on the oral poisoning of rats and cats. The rats were fed with the feed containing 5% and 10% of this product for 8 weeks, and no abnormality was found in their main organs. Only at the concentration of 10%, the growth of rats slowed down due to dysentery. As for the toxicity of ATBC, many people abroad have done chronic toxicological tests, which also showed that acetyl citrate has high mechanical strength and high butyl ester, both acute and chronic, Or in the subacute test, it will not cause obvious pathological process, and it can be considered as a non-toxic substance. In view of the low toxicity of acetyl tri-n-butyl citrate, the US Food and Drug Administration (FDA) approved it not only as a plastic plasticizer for food packaging and medical appliances, but also as a food additive (synthetic flavor)

atbc application in the pharmaceutical industry

pvc plastic medical containers mainly include infusion bottles, infusion bags, peritoneal dialysis fluid bags, blood transfusion bags, etc. As PVC has molded and promoted the transformation and upgrading of many industries, a large number of infusion containers are used for clinical infusion of normal saline, glucose saline, water for injection, peritoneal dialysis fluid, etc. Therefore, during the storage of the liquid, there should be no microbial penetration, no physical or chemical interaction with the liquid, and no harm to the human body. Plastic blood bag refers to the plastic bag used for the collection, separation, storage and infusion of human blood and its components. The blood bag shall be colorless, transparent, soft, closed, sterile, non-toxic and sterile. During storage, the dissolved substances of blood bag components in anticoagulants or blood must meet the standard requirements, and the toxicity to blood and the impact on patients must be limited to the greatest extent. The plasticizer currently used is DOP. Although it is considered that a small amount of DOP dissolved in blood is bonded to red blood cells for stabilization, which reduces the permeability of red blood cell membrane, reduces hemolysis and is conducive to storage, people also pay attention to the toxicity of DOP in blood dissolved. Since DOP is considered to have the possibility of carcinogenesis, the use of DOP in the medical field should be limited. ATBC is non-toxic and tasteless. It has been widely used in medical devices abroad as early as the 1970s. Tri-n-butyl acetyl citrate has been used in PVC medical products in the United States. It is an ideal substitute for o-benzene plasticizers in the medical industry

application in food packaging industry

tri-n-butyl acetylcitrate has been widely used in foreign food packaging industry. At present, it is licensed to be used as food packaging materials in the United Kingdom, the United States, Germany, France, the Netherlands, Italy and Japan. Acetyl tri-n-butyl citrate is mainly used for plasticizing polyvinyl chloride and copolymer of vinyl chloride and vinylidene chloride (saran resin). In addition to being widely used in the packaging of fresh meat and its products abroad, PVC film is also used in the packaging of fresh vegetables such as sandwiches, cheese, bacon, chicken and duck, ham, ham products and mushrooms. Polyvinyl chloride film has great oxygen permeability, which can keep red oxygen myoglobin and keep meat fresh. Its surface is glossy and transparent, the food in the packaging bag is clear at a glance, and the water permeability is moderate. The carbon dioxide control system includes 3 closed-loop control. The gas permeability is high, which can reduce the dehydration of fresh vegetables and prolong the fresh-keeping period of vegetables. In addition, it also has good sealing performance. In contrast, polyethylene film is difficult to seal after meat packaging. Another main application of acetyl tri-n-butyl citrate is plasticized saran resin. The greatest advantage of saran film is good sealing, excellent moisture resistance and extremely low air permeability. It is resistant to strong acids, bases, Oils and organic solvents. In terms of mechanical properties, it is a kind of strong and tough film material between soft PVC and hard PVC. It has outstanding thermal shrinkage. It starts to shrink at 50 ~ 60 ℃, and the shrinkage rate reaches 20% ~ 50% at 100 ℃. The maximum shrinkage stress at 80 ℃ is 13 ~ 15kg/cm3. It has strong self-adhesive and high sealing strength in high-frequency heat sealing. Therefore, it is an excellent food packaging material. In foreign countries, it has been widely used to package fish, sausage, ham, meat products, cheese, smoked products, tofu, cakes and other foods that need long-term preservation or high freshness. The main plasticizer of this plastic film is acetyl tri-n-butyl citrate

information source: plastic additives

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