Development status and analysis of China's pharmac

Development status and analysis of China's pharmaceutical glass packaging market

pharmaceutical glass is a major branch of the pharmaceutical packaging industry and an important part of the entire pharmaceutical industry. Since the reform and opening up, China's pharmaceutical glass packaging industry has developed rapidly, especially the innovative projects created by Evonik will continue in the next few years through the efforts during the "Eighth Five Year Plan" and "Ninth Five Year Plan", which can basically meet the needs of pharmaceutical packaging, and is developing into a pivotal industry. In order to facilitate the relevant people to have a relatively clear understanding and positioning of the current situation and development prospects of China's pharmaceutical glass packaging, shorten the gap with the international advanced level as soon as possible, meet the opportunities and challenges brought by China's accession to the WTO to the pharmaceutical glass industry, and promote the improvement of the overall level of China's pharmaceutical preparations, this paper briefly reviews the main pharmaceutical glass packaging involved in several dosage forms. 1、 Antibiotic powder injection bottle antibiotic powder injection bottle is mainly divided into two types: molding and control. Molded antibiotic bottles: these products are widely used in the packaging of antibiotic powder injections, and the dosage is about 70% of the total amount of antibiotic powder injections. Harbin Pharmaceutical Group, Lukang Pharmaceutical Group and Shijiazhuang Pharmaceutical Group, among the "four giants" of domestic antibiotic subpackaging, basically all use molded antibiotic bottles, with an annual consumption of about 4billion. In recent years, with the rapid development of the pharmaceutical industry, the manufacturing level of the product and the production of catheters have played a very important role in this kind of support, and the quality of the product has been greatly improved. Shandong Pharmaceutical Glass Co., Ltd., the largest manufacturer in China, in order to narrow the gap with similar products in foreign developed countries as soon as possible, while expanding its scale, it pays attention to accelerating the pace of technological transformation and increasing investment in technological transformation. In 1997, it introduced a bottle making production line from Emhart of the United States, whose product quality level has reached and approached the advanced level of similar products in the world, Through the continuous innovation and transformation of the original process technology and equipment, the enterprise trial produced thin-walled lightweight bottles and high white material bottles, which improved the transparency and smoothness of the bottle appearance. At present, there are 10 moulded antibiotic bottle manufacturers in China, with an annual output of about 10billion bottles, and the annual output of most enterprises is less than 500million bottles. There is still a big gap between the level of technical equipment and the level of product quality and the advanced level of similar international products. The task of lightweight has not been fully realized. More and more traditional 800000 units of penicillin have been replaced by large-dose sub packaging. The emergence of various new special drugs and high-grade drugs, coupled with the competition for tube bottles, Molded antibiotic bottles will face the development trend of lightweight, high-grade and large-scale standardization. Controlled antibiotic bottles: North China Pharmaceutical Co., Ltd. is the largest user of such products in China, with an annual consumption of about 1.2 billion bottles. This product has developed rapidly in recent years, and has gradually replaced ampoules for freeze-drying agents and partially replaced molded bottles. Tube bottles are secondary processed products, and their quality level depends not only on the manufacturing process, but also on the quality level of glass tubes. Therefore, enterprises with glass tube production capacity should have certain advantages, but at present, many domestic manufacturers do not have tube drawing production capacity, resulting in large differences in product quality and fierce market competition. Compared with similar international products, there is also a certain gap in the quality of glass. In addition, the product standard level, physical quality level and packaging quality have not reached the advanced level of similar international products. Judging from the development trend of domestic and foreign antibiotic powder injection with low noise and the completion of tensile, contraction, zigzag, shear and other mechanical property experiments of samples, this product will have great development potential. Improving glass material, increasing bottle strength, improving the stability of specification and size, appearance quality and packaging quality, and developing controlled bottles with low expansion coefficient and printing will become the development direction in the future. The pharmaceutical industry put forward in the development guidelines, policies and objectives to 2010: "the production targets of the five preparations are expected to be: the production of 13 billion bottles in 2000 and about 21 billion bottles in 2010, based on an annual increase of 10% in the non split packaging of antibiotics." Antibiotic powder injection is one of the "five dosage forms" of drugs. Among all kinds of conventional drugs, the dosage of antibiotics is the largest. From the analysis of international and domestic market status and development needs, the consumption of controlled bottles has a gradual upward trend, but molded bottles have always occupied the leading position, and more than 70% of antibiotic powder injections are still packaged in molded bottles. The outline of the "Tenth Five Year Plan" for the development of pharmaceutical packaging industry puts forward in the development direction of each dosage form packaging: "powder injection (including biological and biochemical freeze-drying) We should develop high-quality management system and light-weight molded bottles. For a long time to come, these two kinds of products will give full play to their unique advantages in the fierce market competition, and will inevitably compete and replace each other in the development, and achieve greater development in the mutual substitution competition. " 2、 Water injection packaging water injection packaging is mainly glass ampoules. At present, the annual demand of the domestic market is 29billion pieces, and there are many domestic manufacturers. The pharmaceutical industry began to force the elimination of non folding ampoules in 1990, but the problem of easy folding ampoules is still prominent at present. The purpose of folding ampoules is to make ampoules easy to fold, so as to avoid the glass particles formed by filing into the liquid medicine when ampoules are used. Research shows that once glass particles enter the human body with the liquid medicine, they will have serious consequences. In addition, the victims also include medical staff. During injection, ampules are not easy to break and are cut frequently, which brings great hidden dangers and threats to the safety of medication and the use of medical staff. The important reasons for the above problems are: first, the low level of product standards; Second, the product quality, ampoule wall thickness and breaking force indicators are not up to the requirements. In addition, some small and medium-sized enterprises and pharmaceutical enterprises ignore social benefits and ignore ampoule quality and drug safety, which contributes to the emergence of low-quality and low-level competitive marketing in the ampoule Market. According to the market survey and analysis, it is predicted that China's pharmaceutical injections will increase at a rate of 5% per year, and the output will reach 37.5 billion tubes in 2010. 10% - 15% of the injections need ampoules that are resistant to strong acid, strong alkali and light, and 5% of the ampoules need high-quality printing. 3、 At present, the drug packaging containing infusion agent in infusion bottles is still mainly glass infusion bottles. This product is widely used because of its good air tightness, cleanness and transparency, and not easy to deteriorate. However, the reuse of glass infusion bottles has become a major problem that threatens people's safe medication. China's pharmacopoeia requires that the water resistance of the inner surface of glass bottles used for infusion for injection must meet the requirements of grade HC1 and HC2 in gbl2416.1 (iso4802 is equivalent to this standard). There are two kinds of glasses that meet this requirement: one is borosilicate glass with 10% boron oxide (B203), referred to as type I glass, which has excellent chemical stability. At present, there is no infusion bottle made of this kind of glass in China, and there are not many infusion bottles made of this kind of glass in the world. The other is sodium calcium silicate glass with internal surface treatment, which is called turn glass for short. Its internal surface has a very thin silicon rich layer, which can achieve the effect of type I glass, and is widely used internationally. At present, one third of infusion bottles in China are made of this kind of glass, and the other two thirds are made of non-I and non-ii glass containing about 2% boron oxide B2O3). The test shows that the water resistance of type II glass is better than that of non type I and non type II glass, but type II glass is only dealkylated on the inner surface, forming an extremely thin silicon rich layer close to type I glass. If it is reused, due to the damage in the process of bottle washing and filling disinfection, the extremely thin silicon rich layer will be destroyed and the performance will decline. Therefore, it is clearly stipulated in the national standard gb2639, Type II glass is only applicable to disposable infusion bottles. At present, there is a big gap between the manufacturing quality level of domestic infusion bottles and that of similar international products, mainly in the aspects of bottle lightweight, cleanliness, packaging and appearance transparency and uniformity. 4、 The impact of the development trend of the pharmaceutical industry on pharmaceutical glass packaging the pharmaceutical industry is internationally recognized as a "sunrise industry that will never decline". Human survival and health cannot be separated from medicine. In recent years, the economic operation of China's pharmaceutical industry is full of stamina. Experts predict that by 2005, the demand for drugs in China will reach 2.1 billion yuan, a net increase of 94 billion yuan over 2000. Three irreversible factors, namely, the growth of the total population, the aging of the population structure and the migration of rural population to cities, will be the basic conditions for the steady growth of the domestic pharmaceutical market. During the Tenth Five Year Plan period, China's rural pharmaceutical market will be rapidly expanded. It is predicted that by 2010, the total consumption of rural drugs is expected to reach 40billion yuan. There is no doubt that the broad rural pharmaceutical market will provide huge business opportunities for antibiotic generic drugs. The potential development space of China's pharmaceutical market plays a decisive role in the development and growth of pharmaceutical glass packaging. At present, China has become the second largest producer of bulk drugs in the world, and the output of antibiotics and vitamins is among the best in the world. China has been exporting a large number of antibiotic raw materials. In addition, the growth of the demand for imported drugs has been curbed, and the import volume of preparations has declined. The most affected is the imported antibiotics, whose market share has been replaced by garden drugs and "joint venture drugs". In addition, the high proportion of antibiotics used due to the abuse of antibiotics is common in Asian developing countries. Therefore, for a long time to come, the leading role of antibiotics is still generic drugs, which are of high quality and low price, It meets the needs of more than one billion Chinese people. As far as the glass bottles containing antibiotics are concerned, they will still show a steady growth trend. With the progress of society, the improvement of people's living standards and the accession to WT0, the proportion of the use of various new drugs, special drugs and high-end precious drugs will gradually increase. Such drugs will put forward higher demand for the upgrading and upgrading of pharmaceutical glass. This development trend can drive to improve the added value of pharmaceutical glass packaging products